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Recently, there is evidence to suggest a role for the MAOA enzyme in the development of GBM in males – the higher risk group for developing the tumor ( C3 in glioma, with promising in vitro data on glioma cell lines and patient-derived glioma cells ( C3 in vivo , with no detectable distribution to other organs, leading to increased survival of the mice bearing intracranial tumors from TMZ-resistant human glioma cells ( Figure 4 PARPi: Rucaparib Poly ADP ribose polymerase (PARP) inhibitors have shown promise in the treatment of many cancers, with several clinical trials underway to expand their indications (NCT04053673, NCT01311713)

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