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1970's - 1980's: GRAS Affirmation based on the SCOGS Review After receiving a final SCOGS report, FDA reviewed the report and related information When appropriate, FDA issued a notice of proposed rulemaking to affirm GRAS status If, after reviewing comments to the proposal, FDA concluded that the available data and information supported GRAS status, FDA issued a final rule affirming GRAS status by amending 21 CFR 184 (direct food ingredients) or 186 (indirect food substances)

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[PMID: 16403733] [15] Colgate EC, Miranda CL, Stevens JF, Bray TM, Ho E