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Under DCM conditions, elevated 4-HNE levels have been shown to upregulate ACSL4—a key enzyme catalyzing PUFA esterification—and concurrently downregulate GPX4, the primary antioxidant enzyme responsible for reducing lipid hydroperoxides (Gawargi and Mishra, 2023)

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Animal models have shown that PNAs are responsible for neutrophil recruitment in various cardiovascular and inflammatory diseases