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However, one report suggests that this is the case 48 , and one other study suggests that catalase could be the target of inhibitory p50 homodimers, since its promoter is bound by p50 in unstimulated cells and catalase is down-regulated when canonical NF-κB activation occurs 49

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En su forma nativa, el IGF-1 está estrechamente regulado por estas proteínas, lo que limita su actividad circulante