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Conclusions In summary, our findings indicated that berberine conferred hepatoprotective effects in tilapia by enhancing antioxidative and immune capacity, reducing inflammation, and improving lipid metabolism (Figure 8)

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Indeed, there are case reports of monozygotic twins harboring the exact same mutation, both with elevated serum very long chain fatty acids (indicating a similar metabolic defect of peroxisomal lipid processing), where one boy is affected clinically and radiologically, while his twin brother is completely normal (Korenke et al., 1996)