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It is used together with a reduced-calorie diet and increased physical activity for weight loss and to help keep the weight under control in adults who have: a BMI of 30 kg/m² or greater (obesity) or a BMI of at least 27 kg/m² but less than 30 kg/m² (overweight) and weight-related health problems (such as prediabetes, type 2 diabetes, high blood pressure, abnormal levels of fats in the blood, breathing problems during sleep called ‘obstructive sleep apnoea’ (OSA) or a history of heart attack, stroke or blood vessel problems)

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Before human activities became significant, removals from the atmosphere were roughly in balance with additions