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GPX4 Independent Ferroptosis Pathway Although GPX4 is the core molecule of ferroptosis, we have now found other pathways that influence PLOOH synthesis and ferroptosis ( The first is the ferroptosis inhibition protein 1(FSP1) (58–60), which can reduce the mevalonate pathway produced ubiquinone translate to ubiquinol, suppress production of PLOOH, and eventually inhibit ferroptosis (58)