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Consequently, ferroptosis, cuproptosis, and disulfidptosis may involve interrelated crosstalk mechanisms involving glycolysis and oxidative phosphorylation in the context of circulatory disturbance

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The discovery that NNMT expression is dramatically elevated in adipose tissue of obese humans and animal models, and that NNMT inhibition or knockdown prevents diet-induced obesity and improves metabolic health, has catalyzed intense research interest in NNMT as a therapeutic target for obesity, metabolic syndrome, and related conditions

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