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Visceral fat, liver fat, and metabolic profile: The Stanley JAMA trial The most comprehensive single trial documenting both visceral adipose tissue and liver fat outcomes was a 2014 double-blind, placebo-controlled trial by Stanley, Feldpausch, and colleagues in JAMA , which randomized 50 HIV patients with abdominal fat accumulation (tesamorelin n=28, placebo n=22) to tesamorelin 2 mg subcutaneously daily or placebo for 6 months