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Of note, when melatonin is taken 4 h before the sleep midpoint, i.e., at bedtime, the low dose of 0.5 mg does not shift the circadian rhythm, while the 3.0 mg dose will cause a phase delay

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10.1016/j.spinee.2014.12.003 80 Gutierrez MillanC.Zarzuelo CastanedaA.Sayalero MarineroM