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The animal data and mechanistic understanding are compelling, but this peptide should be approached with the understanding that human clinical validation is still forthcoming

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83,86 Non-canonical NF-κB signaling activated by receptors such as CD40, B lymphocyte stimulating factor receptor (BAFF-R), and lymphotoxin beta receptor (LTβR) involves the degradation of TRAF3, which is dependent on cIAP1/2 and TRAF2