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Therefore, this resistance mechanism deserves our attention, as studying this phenomenon is crucial for enhancing the anti-tumor efficacy of targeted therapies and guiding drug development
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Under high glucose conditions, Rho A is activated, leading to elevated intracellular oxidative stress, increased release of inflammatory cytokines (e.g., TNF-α and IL-1β) from renal tubular epithelial cells, and changes in the expression of fibronectin, CTGF, TGF-β1, collagen type IV, and E-calcineurin, which regulate calponin-mediated cell-cell adhesion, as well as increased pro-fibrotic growth factor, and expression of extracellular matrix components and extracellular matrix components