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Slower titration for sensitive patients If you experienced significant GI side effects on semaglutide, your provider may recommend a slower approach: Staying at 2.5 mg for 6 to 8 weeks instead of 4 Moving to 3.75 mg (compounded only) before 5 mg Extending each dose level by 2 weeks based on side effect severity This conservative approach takes longer to reach therapeutic doses but results in better long-term adherence