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6 , 48 Moreover, studies of genome-wide associations identified alleles shared between SLE and pSS patients, such as STAT4, interferon (IFN) regulatory factor 5 (IRF5), B lymphoid tyrosine kinase, tumor necrosis factor (TNF) α-induced protein 3-interacting protein 1, human leukocyte antigen (HLA) complex group 22, chromosome 7 open reading frame 72 (C7orf72), C6orf15, C6orf10, neurogenic locus notch homolog protein 4, butyrophilin-like protein 2, PR domain zinc finger protein 10, autophagy-related 5 protein, Ikaros family zinc finger protein 1, as well as HLA molecules including HLA-DRA, HLA-DQA1, HLA-DQB1, HLA-DQA2, HLA-DPA1, and HLA-DPB1