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b , SDS-PAGE gel showing native eluates of GST-Nup60(285-318) and Nup85(1-564)•His 6 -Seh1 constructs used for the in vitro binding assays presented in Fig

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In addition, mutations in the TAF15 gene have been implicated in the pathogenesis of familial and sporadic ALS, and the TAF15 protein also forms prion-like aggregates in the cytoplasm of spinal cord neurons of rats, leading to increased neuronal toxicity [16,23,24]