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Contrary to some of the above conclusions that exogenous H 2 S ameliorates HCC by activating autophagy, exogenous H 2 S improves liver diseases and nervous system diseases by inhibiting autophagy-mediated cell death ( 2.1.3 Exogenous H 2 S enhances doxorubicin sensitivity to hepatocellular carcinoma cells by inhibiting the outflow of doxorubicin One of the most vital limitations of cancer chemotherapy is that the anti-cancer response of cancer patients decreases over the extended treatment period