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Mechanistically, HGF inhibits inflammatory M1-like macrophage production of pro-inflammatory cytokines and chemokines (such as IL-1β, IL-6, TNFα, CXCL1, CXCL10, and CCL2) by disrupting nuclear factor NF-κB signaling ( It has also been shown that HGF stimulates macrophage differentiation in dendritic immune-suppressive cells, thus facilitating the induction of T lymphocyte regulators, associated with a pivotal role in anti-inflammation