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88 Inspired by natural peptides, the Sando group investigated the effect of substituting backbone amides with ester groups, a class of compound known as depsipeptides whose permeability properties had hitherto not been studied (Figure 7C)

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The bivalent GSH conjugates of BDEA and EDEA are able to produce inhibition by slow but tight binding to GSTM, which have the highest affinity for GSTM retrievable to date