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3.2 Destruction of periodontal soft tissues The integrity and function of PDLFs, essential for soft−tissue homeostasis, are compromised by ferroptosis through a two−fold assault on collagen: synthesis is reduced because PDLF viability and activity are impaired, while degradation is accelerated by ferroptosis−associated ROS and pro−inflammatory mediators (50)

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Sixty years old is the breakpoint of human frontal cortex aging