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Kasper et al., eds., McGraw-Hill, New York (2005)

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Based on a one-compartment PK model (WinNonlin/Phoenix 6.3) of mouse, PK parameters (average plasma concentrations at steady-state [C ave-ss ] and maximum plasma concentrations at steady-state [C max-ss ]) were simulated for the three alternative dosing regimens in addition to the daily regimen (Fig