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Drug metabolism can occur in most cells and organs, but specific organs within the body are considered the primary metabolizing organs (Figure 5.1)

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Additionally, in the eye ascorbate-derived L-erythrulose gives rise 3-deoxythreosone, a reactive osone that glycates lens proteins [103], [104] and C5 aldonic acids which may be converted to D-xylulose 5-P and enter central metabolism via the pentose phosphate pathway [64], [105], [106]