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Metformin significantly reduces TPOAb and TgAb levels in patients with HT and subclinical hypothyroidism, leading to the reduction in TSH

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Neither, in general, can reversed-phase HPLC purity: disulfide isomers can co-elute, and even when they separate, an area-percent figure at a single wavelength tells you the peaks are different, not which peak is the folded protein