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Furthermore, surface expression assays revealed that the majority of LOF missense variants result from misfolding, ER retention, and defective membrane trafficking [159], while the remaining ones exhibit impaired transporter function despite GAT1 correct localization [157]

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Botulinum neurotoxin types A, B, and E: fragmentations by autoproteolysis and other… [PMID: 16323041] Laboratory literature summary: Botulinum neurotoxin types A, B, and E: fragmentations by autoproteolysis and other mechanisms including by…