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A 2018 Cochrane systematic review comparing oral with intramuscular B12 found that high-dose oral B12 (1,000 to 2,000 mcg) normalised B12 levels about as well as injections, though the reviewers rated the evidence as low quality

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The 12-week trial showing 2.6 kg fat loss versus 0.8 kg placebo was run at 1 mg/day