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In both hepatic and pulmonary fibrosis, TGF-β1 has been shown to target GSH synthesis (see above under GCLC regulation) [15,73,82]

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In addition, many important issues need to be further explored, such as the mechanism of the superimposed effect and its safety when polyphenols are applied in combination, the possible interactions with other chemotherapeutic agents such as 5 - fluorouracil, paclitaxel analogs, gemcitabine, pemetrexed, etc., as well as whether oral polyphenols have an impact on ototoxicity by regulating the intestinal flora