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instead observed that MetHb, present in plasma in high concentrations in cases of SCD, can interact with NO, leading to the production of methemoglobin nitrate and iron-nitrosemoglobin complexes, which reduce the plasma concentration of NO, favoring vasoconstriction [44,45]

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Such Tregs include type 1 Tr (Tr1) cells that secrete high levels of IL-10 [86,90]