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In fact, because its thiol is susceptible to pH and alkaline phosphatase, it acts only in normal tissues, without affecting the anticancer effects of chemotherapy and ionizing radiation [338,339,340]

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In addition, Ub and Ub-like proteins (Ulp) have a highly hydrophobic inner core and a hydrophilic surface that, together with such a rapid folding, may explain the SUMO’s behavior as a nucleation site for the proper folding of target proteins (Malakhov et al., 2004

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