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This in turn overwhelms the degradation systems, and produces the activation of the glia inducing neuroinflammation, a process that per se increases the generation of further oxidative stress leading to a self-perpetuating cycle, and finally to neuronal loss of specific brain region such as the hippocampus and cerebral cortex in AD and substantia nigra in PD

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(152) employed machine learning-assisted multi-omics analysis to reveal that serum branched-chain amino acid (BCAA) levels were significantly elevated in DKD patients, closely associated with gut microbiota functional reprogramming