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According to the Mounjaro SmPC, the most frequently reported side effects include: Nausea (very common) Vomiting (very common) Diarrhoea (very common) Constipation (very common) Abdominal discomfort or bloating (common) Reduced appetite (very common) Dyspepsia (indigestion) (common) These effects occur because tirzepatide slows gastric emptying—the rate at which food leaves the stomach—which is part of its therapeutic mechanism for improving glycaemic control and promoting weight loss

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The onset of symptoms depends on factors such as the type of treatment used How Long Does SIBO Die-Off Last