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GSH imbalance and/or deficiency in the neurons is involved in the pathogenesis of brain disorders, including AD, amyotrophic lateral sclerosis (ALS), autism, bipolar disorder, Huntington’s disease (HD), multiple sclerosis (MS), Parkinson’s disease (PD), and schizophrenia [5]

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The substrates for the AMACR encoded enzyme include (2 R )/(2 S )-pristanoyl-CoA and the bile acid precursor molecule (25 R )/(25 S )-trihydroxy cholestanoyl-CoA