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Overexpression of a ATP13A2 orthologue in yeast was shown to impart zinc resistance (van Veen et al., 2014)

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In certain embodiments, such modulation toward a pro-inflammatory state may be measured in a variety of well-known ways, including but not limited to one or more of the following: a) increased cluster of differentiation 80(CD80), CD86, MHCII, MHCI, interleukin 1-beta (IL-1 beta), IL-6, CCL3, CCL4, CXCL10, CXCL9, GM-CSF and/or tumor necrosis factor alpha (TNF-alpha)