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Asimismo, la tiamina desempeña un importante papel en los mecanismos relacionados con la conducción nerviosa (interviene en la formación de mielina) de los nervios periféricos y en la transmisión neuromuscular, ya que interviene en la síntesis de la acetilcolina (mediador químico neuronal)

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However, evidence suggests that there is a divergence point, related to obesity severity, at which mortality risk becomes increasingly modulated