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Figure 3 To further investigate the potential regulatory mechanisms influencing GLO-1 expression in cancer, we examined DNA methylation alterations as a key epigenetic modification

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This review will discuss the enzymes regulating major aspects of pyruvate metabolism, their structures, and the biochemical bases for the reactions they catalyze, the roles dysfunctional forms play in causing human disease, and major diseases for which aberrant pyruvate metabolism is a prominent characteristic