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found a new biological element that can directly react with phenolic antioxidants (such as t-butylhydroquinone) in mice, and named it as antioxidant response element, also known as electrophile response element (EpRE) ( Keap1-Nrf2 Pathway and Autophagy The selective autophagy substrate p62 contains an ETGE-like motif, STGE, which could be phosphorylated by mTOR complex 1 to bind to Keap1 with higher affinity (Taguchi et al., 2012)

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ECM stiffness can influence responses to anticancer agents by regulating access to chemotherapy 148 and potentially forming a physical barrier to promote resistance 149 (FIG