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Results from another study indicated that 4-HNE-binding to collagen II could lead to multiple abnormalities of chondrocyte phenotype and function, suggesting it may contribute to interrupting the extracellular matrix (ECM) homeostasis [79]
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Despite these tremendous advances in diagnostic and therapeutic armamentarium, the conduct of thyroid disorders is still hampered by several limitations and challenges that include the difficulties of early and correct diagnosis-especially for autoimmune thyroid diseases-side effects of the current treatment modalities and imprecision in personalized care (Jacob et al
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