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A double-blind, placebo-controlled trial in 90 HIV-positive patients with symptomatic distal symmetrical polyneuropathy found no benefit of intramuscular injection with 1 g/day of ALCAR for two weeks in the intention-to-treat analysis, but there was some pain relief in the group of 66 patients who completed the trial (84)

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17 The GATHER1 trial, conducted over an 18-month period, revealed numerically better outcomes in low-luminance best-corrected visual acuity (BCVA) of patients undergoing avacincaptad pegol treatment as compared to the corresponding sham, suggesting that treated patients might have an easier time reading in low light conditions or viewing objects that require sharper vision