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Conversely, certain ethnic populations, particularly those having increased frequency of the mutated PGP (e.g., of Caucasian descent, or non-African descent) may require less pharmaceutical compositions in the formulation due to an effective increase in efficacy of such compositions as a result of the increased effective absorption (e.g., less PGP activity) of said composition

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The IGF-1 pathway could still be a promising target to treat muscle atrophy where both autophagy and UPS are activated, and protein synthesis is decreased, as IGF-1 activation could theoretically normalize all of these pathways