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Importantly, adoptive co-transfer experiments revealed impaired infiltration of SUCNR1-knockdown CD8 + T cells relative to SUCNR1-proficient CD8 + T cells in an immunocompetent subcutaneous B16 melanoma tumor model in mice, while administration of the SUCNR1 agonist cis -epoxysuccinic acid significantly decreased tumor volume in this model

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P22077/P5091 Ubiquitin-Specific Peptidase 7 (USP7) regulates p53 expression by preventing MDM2 degradation from the ubiquitin-proteasome system