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The signals discussed in peer-reviewed preclinical work include: Activity within cellular signaling pathways studied in laboratory models Interactions with mucosal cell models in preclinical research Binding interactions with melanocortin receptors , particularly MC1R and MC5R, in laboratory studies Favorable tolerability in short-term animal studies What the research does not yet establish: large-scale randomized human trials, long-term safety data over years of use, or definitive use guidance for intranasal administration in humans

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