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Abstract Introduction: Motivation is a key driver in achieving goals and performing daily tasks, involving cost–benefit valuations of the amount of effort required for a particular reward and can be influenced by socio-environmental factors and neurological conditions that may impact the brain reward circuitry

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However, with in vitro patch clamp recording, direct application of acetaminophen to the spinal cord did not change miniature EPSCs (mEPSCs), but AM404 did