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Reasons for this difference of IA and IAA to inactivate GAPDH could be that the active center of the enzyme binds the negatively charged IA better than the neutral IAA and/or that for sterical reasons IA fits better than IAA into the active side of GAPDH in an orientation that facilitates the alkylation of the thiol group in the active center

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Human BPC-157 evidence is still limited One small retrospective human report looked at intra-articular BPC-157 for knee pain