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In puppies younger than 11 weeks of age, histological evidence of bone marrow hypocellularity was observed at higher frequency and greater severity in puppies treated with CERENIA compared to control puppies

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These abnormalities are rescued by the treatment with b-RA [51], which, as previously mentioned, rescues CoQ deficiency due to mutations in Coq7 or Coq9 [41,51,52,53]