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Once adequate circulating GH levels are reached, the hypothalamus turns off GHRH stimulation and releases inhibitory somatostatin to temporarily halt GH secretion in a process known as “negative feedback.” In addition to GHRH and somatostatin, the GH axis is also regulated by the interplay of other factors, such as the hormones ghrelin (a GH-stimulatory peptide secreted from the stomach) and IGF-1 (an insulin-like hormone produced by the liver in response to GH), as shown below: Figure 1: GH Feedback Regulation (10) All of these elements are integrated into a synchronized feedback loop consisting of alternating GH stimulation and inhibition which results in the sporadic or pulsatile secretion of GH

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evaluated the effect of boiled or steamed Brussels sprouts, rich in GLSs (220 mg/100 g), on thyroid function in healthy human subjects

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