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Some thiols have poor bioavailability when taken orally and are degraded in the gastrointestinal tract (e.g., due to enzymatic degradation as in the case of glutathione and γ-glutamyltransferase) (Schmitt et al., 2015)

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Other studies have also reported that peritumoral stromal neutrophils and mesenchymal cells secrete high levels of HGF, which drove high rates of proliferation, invasion and metastasis in HCC by promoting the EMT (He et al., 2016)