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Even though the cure of infection is likely to reduce the likelihood of developing liver cancer, the direct impact of integrated HBV DNA and the viral proteins (eg, HBsAg and HBx) expressed from integrants on cellular gene expression and hepatocyte homoeostasis will need to be carefully considered

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Interestingly, there was a simultaneous and significant increase in fat-free mass, which remains unexplained and could be linked to changes in protein metabolism reported to occur in HIV infection (25)