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Every-other-day compared to weekly interferon-beta 1a over the 2 years showed that the interferon-beta 1b group had a statistically significant lower rate of annualized relapses (RR: 0.44), lower rate of new T2 lesions (RR: 0.6), lower proportion of patients with disability progression, and longer time to disability progression

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Investigations when indicated: * Anoscopy/proctoscopy to visualize internal hemorrhoids